Data Analysis NIH launches Genotype-Tissue Expression projectThe National Institutes of Health today announced awards to support an initiative to understand how genetic variation may control gene activity and its relationship to disease. Launched as a pilot phase, the Genotype-Tissue Expression (GTEx) project will create a resource researchers can use to study inherited susceptibility to illness and will establish a tissue bank for future biological studies. Each cell in the human body contains a complete set of genes, yet not every gene is turned on, or expressed, in every cell in the body. To function properly, each type of cell turns different genes on and off, depending on what the cell does. For example, some genes that are turned on in a liver cell will be turned off in a heart cell. In addition, recent genome-wide association studies have identified several hundred common genetic variants — inherited changes in the DNA sequence of the human genome — that play a role in an individual’s susceptibility to complex human illnesses such as heart disease, mental illnesses, cancer and diabetes. GTEx seeks to combine these two observations to generate data to study systematically how gene expression is regulated in different organs in the… Read full this story
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