Friday, November 31, 2017, London, UK: Researchers from the Biogerontology Research Foundation , Department of Molecular Neuroscience at the Swammerdam Institute for Life Sciences at the University of Amsterdam, and the Department of Neurobiology, Care Sciences and Society at the Karolinska Institute (http://ki.se/en/startpage) announce the publication of a paper in Translational Neurodegeneration, a BioMedCentral journal, titled RNAi mechanisms in Huntington’s disease therapy: siRNA versus shRNA. After many years of development, RNAi therapeutics are nearing the clinic. There are several variants on RNAi therapeutics, such as antisense oligonucleotides (ASOs), short-hairpin RNA (shRNA), small interfering RNA (siRNA), et cetera. The researchers’ paper aimed to answer the question of why RNAi therapeutics for nucleotide repeat disorders (specifically Huntington’s, a devastating genetic neurodegenerative disease), have lost favor in recent years. After a phenomenal amount of excitement, these therapies were hindered by problems like molecular stability, dosing, and transcriptional control of the gene therapeutic construct. “We compared various RNAi-based therapeutic modalities available for the treatment of Huntington’s Disease and offered mechanistic proposals on how to break through current barriers to clinical development. One key problem has proven to be modulating the expression level of shRNA constructs, which would otherwise be the clear frontrunner among ASOs,… Read full this story
- Scientists identify 'microprotein' in the brain that puts a person at a 'substantial' risk of developing Alzheimer's later in life
- Five People With Lupus Went Into Complete Remission After Immunotherapy
- The Spring Of Cryobiology: One Enabling Technology That Will Help Build The New Industry Of The Future
- Earliest Invasive Cancer Found in 3,000-Year-Old Skeleton
- NVIDIA Expands Large Language Models to Biology
BGRF and SILS scientists analyze viability of shRNA therapy for Huntington's Disease have 265 words, post on www.eurekalert.org at December 1, 2017. This is cached page on Vietnam Art News. If you want remove this page, please contact us.